Sample Size Calculation and Statistical Analysis

(4/06/2011)

We give some examples of power analysis/sample size paragraphs that can be adapted and specialized for your proposals.  These examples have actually been used and considered adequate in proposals.  However please remember that reviewers differ considerably in their views of what constitutes an acceptable power analysis; e.g., some require sample size/power computations for each hypothesis or minimum effect size hypotheses.  We recommend giving as much detail as is possible within the current page limitations for proposals, and whenever possible linking effect sizes to metrics reflecting potential clinical outcomes.

Table 1

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